The Induction of Ovarian Tumours in Mice with 9: 10-Dimethyl-1: 2-Benzanthracene

Metabolic and carcinogenic studies with 9, 10-dimethyl-1, 2-benzanthracene.

Emulsions Containing 9,1O-Dimethyl-1, 2-Benzanthracene

Emulsions of fat suitable for intravenous ad ministration have been used in this laboratory as @ source of calories, as an aid in the study of lipid metabolism, and as a vehicle for fat-soluble ma tenials. The latter use has been of value in studies with rats on the effects of the intravenous injection Cof carcinogenic hydrocarbons. Several investiga tions have been reported in which emulsions ...

Induction of skin tumors in the mouse with minute doses of 9, 10-dimethyl-1, 2-benzanthracene alone or with croton oil.

Tumors have been induced frequently in the laboratory mouse following exposure to the carcinogenic hydrocarbons (6). In many of these studies, the chemicals were applied continuously and at a relatively high concentration. Cramer and Stowell (5) compared the tumorigenic effectiveness of e0-methylcholanthrene when applied continuously or discontinuously to the skin of mice and concluded that ski...

A Transplantable 9, 10-Dimethyl-1,2-Benzanthracene Sarcoma in the Syrian Hamster*

Comparatively little has been published on the use of the hamster in cancer research and only two reports, including some 15 instances, of spontaneous tumors are available (1, 9). The earliest experimental work appears to be Gye and Fould's (9) production of a mixed-cell sarcoma in two males by injecting 3,4-benzpyrene, in 1939. A year later Halberstaedter (11) reported the production of a simi...

9, 10-Dimethyl-1,2-Benzanthracene as a Highly Potent Carcinogen for the Rabbit's Skin*

There are many types of investigation connected with the tumor problem for which a large laboratory animal such as the rabbit would be more useful than a small one such as the mouse. For problems connected with experimental carcinogenesis the limiting factor is, naturally, the availability of a suitable carcinogen. Neither tar nor 3,4-benzpyrene can be considered as suitable for the rabbit: The...